Researchers at the National University of Singapore’s Yong Loo Lin School of Medicine have developed LinAge2, a new biological ageing clock. This model, trained on the US National Health and Nutrition Examination Survey, uses clinical data to estimate biological age. It outperformed existing DNA-based epigenetic clocks like PhenoAge and GrimAge in predicting mortality risk over 10 and 20 years. LinAge2 also showed that individuals with a lower biological age had better gait speed, cognitive performance, and independence in daily activities. The model identified smoking and metabolic syndrome as factors accelerating ageing. LinAge2 aims to enhance personalized medical strategies by integrating into routine check-ups, potentially improving healthspan. The research team is collaborating with NOVI Health to incorporate LinAge2 into health longevity programs and plans to validate the model across diverse populations.
Kyun Jung
@just_kyunjung
·
15h We had to invent units to measure it.
A clock is a unit for time.
A biological clock is a unit for aging.
Understanding those clocks helps us see aging not just as decline, but as data – something we can measure, estimate, and eventually, influence.
I deeply admire the work of
Life Course & Aging
@lifecourseUofT
·
2h Researchers develop an #epigenetic clock which estimates how well someone is #aging instead of focusing on chronological age. The study aims to help clinicians identify at-risk individuals and tailor interventions to ensure healthier lives
@EurekAlert
https://eurekalert.org/news-releases/1085881…
Joseph Takahashi
@CircadianClocks
·
Mar 28 This is the most important paper in the circadian field in over a decade. A completely new clock component that is evolutionarily conserved.
@Eric_E_Zhang
@susanksgolden
@
@SRBR_Outreach
https://rdcu.be/efxV8
David Sinclair
@davidasinclair
·
11h Intravenous FOXO3-enhanced cells outperformed regular stem cells in decelerating multi-organ aging clocks demonstrating their potential as a clinical cell therapy to combat aging and related health issues
ICFSRcongress
@ICFSRcongress
·
Jun 13 New Breakthrough in Measuring Aging:
It’s Not Just About Years; It’s About Function
Aging well isn’t just about living longer, it is about staying independent, mobile, and mentally sharp.
A new study in
@NatureAging
introduces the IC Clock, a revolutionary biological age
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