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95% of Drugs Fail in Humans: Could Organs on Chips Change This?

In a groundbreaking development, researchers in China have successfully created mice with two fathers using CRISPR technology. This complex experiment involved targeting genes that typically require inheritance from both parents, offering insights into genetic imprinting. While human applications are not yet on the horizon, this research enhances our understanding of how genes are expressed differently based on parental origin. Meanwhile, the potential end of animal testing looms as organs on chips, small devices lined with human tissues, show promise in drug testing. These chips could revolutionize medical research, given that around 95% of drugs developed through animal studies fail in human trials. This shift could provide a more ethical and effective alternative to traditional animal testing methods.

Source: www.technologyreview.com

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