A social media influencer, Sidney Raz, was diagnosed with stomach cancer following the tragic loss of his daughter in utero at 26 weeks due to holoprosencephaly. Genetic testing revealed a deletion in his daughter’s DNA, which was also found in Raz but not in his wife. This deletion has been associated with certain cancers, including stomach cancer. Raz, who showed no symptoms prior to his diagnosis, discovered his condition through an endoscopy. He credits his daughter’s DNA for saving his life by prompting the genetic testing. Raz advised viewers to undergo a full panel of CDH1 and CTNNA genetic tests, as these mutations are known to lead to diffuse gastric cancer. Currently in the exploratory phase, Raz is undergoing further tests to determine the cancer’s stage and whether he will need chemotherapy or a stomach removal, scheduled potentially for April 18.
M | O | C Cancer Care & Research Centre
@IndiaOncocare
·
Apr 7 Right-sided colon cancer is often linked to microsatellite instability (MSI-H) and BRAF mutations, commonly seen in hereditary conditions like Lynch syndrome.
Left-sided colon cancer is more associated with chromosomal instability (CIN) and APC, KRAS, or TP53 mutations.
Khalid Jazieh
@kjazieh
·
Apr 4 Grateful to have our work on the genetic landscape of KRAS G12C-positive GI cancers and potential resistance mutations published!
https://aacrjournals.org/clincancerres/article/31/5/899/751939/Identification-of-Candidate-Alterations-Mediating…
Yüksel Ürün
@DrYukselUrun
·
17h Genomic testing in childhood & young adult cancers:
16–18% carry germline variants
Somatic findings guide Dx in up to 95%
Matched therapy? Often possible—rarely given
The science is ready. Let’s make care catch up.
#PediatricCancer #Genomics #PrecisionOncology #cancer
Miruna Popescu, MD
@MirunaPopescu13
·
19h Dr. Jason Hornick on mesenchymal tumors of the GI tract.
Calcifying Nested Stromal-Epithelial Tumor.
As the name implies, also shows psammomatous/dystrophic calcifications.
#IHCpath WT1+ beta-catenin+ CK+ (weak).
CTNNB1 & TERT promoter mutations.
#BSTPath #HMAR_BASTPC25
Luis Lara-Mejía
@LuisLara_M
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Apr 7 A nationwide study (JTO 2025) finds sex and common germline SNPs (e.g. PPAR-α 209G>A) significantly impact #Alectinib toxicity in ALK+ NSCLC.
Female pts had +35% higher drug levels
PPAR-α variant = +26% G3+ toxicity
43% needed dose reduction.
Personalization is
Miruna Popescu, MD
@MirunaPopescu13
·
18h Dr. Jason Hornick on GI tract mesenchymal tumors.
Gastric glomus tumor
Pitfall! Gastric glomus tumors may express synaptophysin DDx with NET! (though expression more patchy & weak than in NET)
Glomus tumors are CK-, SMA+, caldesmon+
#PathTwitter #BSTPath #HMAR_BASTPC25
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